Functional role of exercise - induced cortical organization of 3 sensorimotor cortex after spinal transection 4 5 6
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چکیده
5 6 T Kao, JS Shumsky, EB Knudsen, M Murray, KA Moxon 7 8 9 10 Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen 11 Lane, Philadelphia, PA 19129 12 School of Biomedical Engineering, Science and Health Systems, Drexel University, 3141 13 Chestnut St., Philadelphia, PA 19104 14 15 16 17 18 Address correspondences to: 19 Karen Moxon, PhD 20 School of Biomedical Engineering, Science and Health Systems 21 Drexel University 22 3141 Chestnut St 23 Philadelphia, PA 19104 24 25 215 895-1959 26 215 895-0570 (fax) 27 [email protected] 28 29 30 Running Title: Neuronal Activity in Awake Spinalized Rats 31
منابع مشابه
Functional role of exercise-induced cortical organization of sensorimotor cortex after spinal transection.
Spinal cord transection silences neuronal activity in the deafferented cortex to cutaneous stimulation of the body and untreated animals show no improvement in functional outcome (weight-supported stepping) with time after lesion. However, adult rats spinalized since neonates that receive exercise therapy exhibit greater functional recovery and exhibit more cortical reorganization. This suggest...
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Physical exercise promotes neural plasticity in the brain of healthy subjects and modulates pathophysiological neural plasticity after sensorimotor loss, but the mechanisms of this action are not fully understood. After spinal cord injury, cortical reorganization can be maximized by exercising the non-affected body or the residual functions of the affected body. However, exercise per se also pr...
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Exercise-induced cortical plasticity is associated with improved functional outcome after brain or nerve injury. Exercise also improves functional outcomes after spinal cord injury, but its effects on cortical plasticity are not known. The goal of this investigation was to study the effect of moderate exercise (treadmill locomotion, 3 min/d, 5 d/week) on the somatotopic organization of forelimb...
متن کاملSensorimotor Experience Influences Recovery of Forelimb Abilities but Not Tissue Loss after Focal Cortical Compression in Adult Rats
Sensorimotor activity has been shown to play a key role in functional outcome after extensive brain damage. This study was aimed at assessing the influence of sensorimotor experience through subject-environment interactions on the time course of both lesion and gliosis volumes as well as on the recovery of forelimb sensorimotor abilities following focal cortical injury. The lesion consisted of ...
متن کاملReorganization of the Intact Somatosensory Cortex Immediately after Spinal Cord Injury
Sensory deafferentation produces extensive reorganization of the corresponding deafferented cortex. Little is known, however, about the role of the adjacent intact cortex in this reorganization. Here we show that a complete thoracic transection of the spinal cord immediately increases the responses of the intact forepaw cortex to forepaw stimuli (above the level of the lesion) in anesthetized r...
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تاریخ انتشار 2011